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Do the MTHFR gene polymorphism and down syndrome pregnancy association stands true? a case-control study of Indian population and meta-analysis
Egyptian Journal of Medical Human Genetics [The]. 2016; 17 (1): 87-97
in English | IMEMR | ID: emr-176218
ABSTRACT

Background:

Down syndrome, the most common trisomy 21 arises from abnormal chromosomal segregation. The etiology includes genetic and acquired factors. The main genetic factor that is well appreciated for onset of Down syndrome pregnancy is MTHFR gene polymorphism. But till date, no final conclusion has arrived despite multiple studies on this gene polymorphism
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Index: IMEMR (Eastern Mediterranean) Main subject: Polymorphism, Genetic / Pregnancy / Case-Control Studies / Methylenetetrahydrofolate Reductase (NADPH2) / Genotype Limits: Female / Humans Language: English Journal: Egypt. J. Med. Hum. Genet. Year: 2016

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Index: IMEMR (Eastern Mediterranean) Main subject: Polymorphism, Genetic / Pregnancy / Case-Control Studies / Methylenetetrahydrofolate Reductase (NADPH2) / Genotype Limits: Female / Humans Language: English Journal: Egypt. J. Med. Hum. Genet. Year: 2016