Susceptibility to methamphetamine dependence associated with high transcriptional activity alleles of VNTR polymorphism in the promoter region of monoamine oxidase A [MAOA]
Egyptian Journal of Medical Human Genetics [The]. 2016; 17 (1): 111-114
in English
| IMEMR
| ID: emr-176221
ABSTRACT
Background and purpose:
Monoamine oxidase A [MAOA, Xp11.3; OMIM 309850] can modulate the level of neurotransmitters in the central nervous system. A 30 bp variable number of tandem repeat [VNTR] genetic polymorphism on the promoter region of the MAOA can modulate the transcriptional activity of the gene. Association between this polymorphism and dependency to methamphetamine was investigated
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polymorphism, Genetic
/
Case-Control Studies
/
Promoter Regions, Genetic
/
Minisatellite Repeats
/
Substance-Related Disorders
/
Alleles
/
Monoamine Oxidase
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Med. Hum. Genet.
Year:
2016
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