Analgesic, anti-inflammatory and anti-pyretic activities of Thymus linearis
Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (2): 591-594
in English
| IMEMR
| ID: emr-176395
ABSTRACT
The present study was aimed to investigate the antipyretic, analgesic and anti-inflammatory activity of aqueous methanolic and n-hexane extract of Thymus linearis. For measuring analgesic activity, writhing test, hot plate method and formalin test were performed and abdominal writhing was induced by intra-peritoneal injection of 0.2 ml of 3% acetic acid. While in formalin test, pain was experimentally induced by injecting 25 micro l of 2.5% formalin in left hind paw. In hot plate method, pain was induced thermally by keeping the animals on a hot plate with temperature of about 51[degree]C. Anti-inflammatory activity was assessed by carrageenan induced mice paw edema. For determination of antipyretic activity, pyrexia was induced by subcutaneous injection of 15% yeast. The results showed that both the extracts had significant analgesic activity [p<0.05]; anti-inflammatory activity [p<0.05] and anti-pyretic activity [p<0.05]. Therefore, it was concluded from this study that the extracts of Thymus linearis may be used against pain, pyrexia and inflammation
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pain Measurement
/
Plant Extracts
/
Antipyretics
/
Analgesics
/
Mice
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2016
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