value of bilicheck[registered sign] as a screening tool for neonatal jaundice in the South of Iran

ABSTRACT

The gold standard to assess jaundice in neonates is the serum bilirubin measurement. Blood sampling for the determination of total serum bilirubin [TSB] is painful for newborns and stressful for parents. The Bilicheck[registered sign], a new transcutaneous bilirubinometer, is considered as a more accurate measurement of bilirubin compared to the previous bilirubinometers courtesy of its advanced technology. The objective of this study was to evaluate the correlation between transcutaneous bilirubin [TcB] measurements using the Bilicheck[registered sign] device and TSB in some Iranian neonates and to determine the most reliable cut-off value with the highest sensitivity and desirable specificity for bilirubin measured by the Bilicheck[registered sign] on the forehead. This prospective observational study was conducted in 2011 on 560 healthy neonates with jaundice. TcB was measured using the Bilicheck[registered sign] [Respironic, USA] within 30 minutes of TSB measurement via direct spectrophotometry. The results were assessed by simple linear regression analysis and receiver operative characteristic curve. There was good a correlation between TcB and TSB [r=0.969, r2=0.94], and this was not affected by sex, gestational age, postnatal age, and birth weight. TSB can be calculated through the measurement of TcB and use of the linear regression equation TSB=-0.99+1.06TcB. Sensitivity and specificity of the Bilicheck[registered sign] at the most reliable cut-off value [15 mg/dl] were 96.6% and 99%, respectively. The findings of the present study indicate that the Bilicheck[registered sign] is a non-invasive, simple, easy, and reliable method for bilirubin measurement in neonatal jaundice, especially in neonates with bilirubin levels