Increased bcl-2 protein levels in rat primary astrocyte culture following chronic lithium treatment
IJMS-Iranian Journal of Medical Sciences. 2013; 38 (3): 255-262
in English
| IMEMR
| ID: emr-177164
ABSTRACT
Background:
B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium's neuroprotective effect. However, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disorder. The aim of this study was to evaluate whether chronic lithium treatment also elevates bcl-2 expression in astrocytes compared with neuronal and mixed neuron-astrocyte cultures
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Iran. J. Med. Sci.
Year:
2013
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