Analysis of the DosR regulon genes to select cytotoxic T lymphocyte epitope specific vaccine candidates using a reverse vaccinology approach
International Journal of Mycobacteriology. 2016; 5 (1): 34-43
in English
| IMEMR
| ID: emr-177660
ABSTRACT
Objective/background:
There is an urgent need for a more effective vaccine against Mycobacterium tuberculosis [Mtb]. Although CD4+ T cells play a central role in host immunity to Mtb, recent evidence suggests a critical role of CD8+ T cells in combating Mtb. In the present study, we have predicted HLA antigen class I binding peptides of DosR operon using an in-silico approach. This method is useful as an initial computational filtration of probable epitopes based on their binding ability and antigenicity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Protein Kinases
/
Bacterial Proteins
/
Tuberculosis
/
Immunotherapy, Active
/
Regulon
/
CD8-Positive T-Lymphocytes
/
Epitopes, T-Lymphocyte
/
Mycobacterium tuberculosis
Language:
English
Journal:
Int. J. Mycobacteriology
Year:
2016
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