Effect of curcumin administration against some biochemical alteration induced by acrylamide in adult male albino rats

ABSTRACT

Acrylamide is a chemical used in many industries, found in carbohydrate rich foods cooked at high temperature. Although it is found to be harmful, human are exposed to varying amounts of it in the diet, especially fried food. Curcumin is a herbal agent used in medicine and proved to be protective against many harmful agents. This study was undertaken to assess the protective effect of curcumin against some biochemical alteration induced by acrylamide in male albino rats. The experimental rats were divided into four groups included a control group, a group treated orally with curcumin by supercritical fluid extractor for 30 days, a group treated orally with acrylamide and a group treated orally with curcumin + acrylamide for 30 days. The results indicated that treatment with ACR alone resulted in a significant decrease in the haematological parameters, triglycerides, insulin, creatine kinase and choline esterase while the concentrations of urea, creatinine, ALT, AST and alkaline phosphatase were increased. Treatment with curcumin during ACR treatment reduced the effects induced by ACR, It could be concluded that curcumin exhibited a protective action against ACR-induced biochemical alterations in rats. For this reason, curcumin is recommended to be used in cooked food due to its palatable taste and prophylactic effect