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Angiotensin-converting enzyme gene insertion/deletion polymorphism in Saudi patients with rheumatic heart disease
Saudi Medical Journal. 2015; 36 (2): 176-180
in English | IMEMR | ID: emr-178073
ABSTRACT
To investigate the association between angiotensin-converting enzyme [ACE] insertion/deletion [I/D] polymorphism and rheumatic heart disease [RHD] in Saudi patients. A case-control study was conducted in Saudi RHD patients. Genomic DNA was isolated from 99 RHD patients attending the Pediatric Cardiology Clinic at the Maternity and Children Hospital, Al-Madinah, Saudi Arabia from March 2013 to June 2014, and from 145 age- and gender-matched controls. Patient clinical records were reviewed to report major and minor modified Jones' criteria for diagnosis. The diagnosis was confirmed by echocardiography. The ACE I/D polymorphism was identified by polymerase chain reaction. A significant difference in ACE D allele carriage [DD+ID] distribution between RHD cases and controls was identified [p=0.02, odds ratio = 3.6, 95% confidence interval 1.2-10.8]. The D allele carriage was significantly associated with development of mitral valve lesions alone [p=0.03]. The ACE I/D polymorphism is associated with an increased risk of RHD in the Saudi population. Further studies are needed to confirm our findings and to understand the molecular mechanisms underlying this association
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Index: IMEMR (Eastern Mediterranean) Main subject: Polymorphism, Genetic / Rheumatic Heart Disease / Case-Control Studies / Polymerase Chain Reaction / INDEL Mutation Limits: Female / Humans / Male Language: English Journal: Saudi Med. J. Year: 2015

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Index: IMEMR (Eastern Mediterranean) Main subject: Polymorphism, Genetic / Rheumatic Heart Disease / Case-Control Studies / Polymerase Chain Reaction / INDEL Mutation Limits: Female / Humans / Male Language: English Journal: Saudi Med. J. Year: 2015