Antiproliferative xanthone derivatives from Calophyllum inophyllum and Calophyllum soulattri
Pakistan Journal of Pharmaceutical Sciences. 2015; 28 (2): 425-429
in English
| IMEMR
| ID: emr-178136
ABSTRACT
Structure-activity relationships of eleven xanthones were comparatively predicted for four cancer cell lines after the compounds were subjected to antiproliferative assay against B-lymphocyte cells [Raji], colon carcinoma cells [LS174T], human neuroblastoma cells [IMR-32] and skin carcinoma cells [SK-MEL-28]. The eleven chemical constituents were obtained naturally from the stem bark of Calophyllum inophyllum and Calophyllum soulattri. Inophinnin [1] and inophinone [2] were isolated from Calophyllum inophyllum while soulattrin [3] and phylattrin [4] were found from Calophyllum soulattri. The other xanthones were from both Calophyllum sp. and they are pyranojacareubin [5], rheediaxanthone A [6], macluraxanthone [7], 4-hydroxyxanthone [8], caloxanthone C [9], brasixanthone B [10] and trapezifolixanthone [11]. Compound 3 was found to be the most cytotoxic towards all the cancer cell lines with an IC[50] value of 1.25[micro]g/mL while the simplest xanthone, compound 8 was inactive
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Plant Extracts
/
Cell Line, Tumor
/
Xanthones
Language:
English
Journal:
Pak. J. Pharm. Sci.
Year:
2015
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