Acetylator phenotyping of sulfadimidine in a randomly mixed population

ABSTRACT

The world populations are classified into slow and fast acetylator phenotypes based on their genetic Lineage. Though some genetic intermixing exists in most populations, trend in genetic phenotypes in randomly mixed populations have not been reported. The population occupying the northwestern part of the Indian subcontinent [now Pakistan] is a unique example of prolonged and random mixing of divergent races. This study reports the genetic phenotyping in this randomly mixed populations and concludes that divergent phenotyes, randomly mixed, yield a perfect 50% distribution of slow and fast acetylators. The metabolic acetylation status in the subject population was studied using Sulfadimidine as the marker at a dose of 3 mg/kg. The pharmacokinetics of Sulfadimidine and its acetylated metabolite were studied. The acetylation of Sulfadimidine was found to be bimodal with equal distribution between rapid and slow acetylators. The pharmacokinetics parameters of sulfadimidine and its acetylated metabolite, except renal clearance, differed significantly between the rapid and slow acetylators