Effects of the diclofenac sodium [NSAID] on collagen connective tissue fibres in caecal mucosa of albino rats

ABSTRACT

To evaluate the effects of diclofenac sodium [NSAID] on Collagen connective tissue fibers of albino rats. An animal study carried on experimental albino rats. An animal study carried out in the Department of Anatomy, Basic Medical Sciences Institute [BMSI], Jinnah Postgraduate Medical Centre [JPMC], Karachi. Diclofenac sodium was administered to male albino rats at a dose of 2 mg/kg body weight orally once daily for two weeks. These animals were sacrificed, Caeca were identified and removed, opened along mesenteric border, fixed in alcoholic formalin. Embedded in paraplast, 4 um thick sections were cut on rotary microtome, stained with Mallory's trichrome Connective tissue stain. The histomorphological features of caecal mucosa were compared with those in the control animals. The study revealed that diclofenac sodium administration produced and increased amount of Collagen connective tissue fibers forming a sub-epithelial collagen band in caecal mucosa of albino Rats. The results suggest that diclofenac sodium causes. Severe caecal mucosal damage in albino rats