Comparison of in vitro antibacterial activity of levofloxacin and gatifloxacin

ABSTRACT

Clinical isolates including Staphylococcus. aureus, Escherichia coli, Klebsiella pneumonia, Pseudomonas. aeruginosa and Salmonella. typhi were obtained from different pathological laboratories and medical center were included in the study. Comparison of in vitro antibacterial activity of levofloxacin and gatifloxacin was carried out by ICLS reference Disk diffusion [Kirby-Bauer] method. An attempt has been made to measure the zone of inhibition produced by Levofloxacin and gatifloxacin against these clinical isolates. Comparison of susceptibility results indicated that both Levofloxacin and Gatifloxacin has excellent in vitro antibacterial activity but gatifloxacin had relatively broad spectrum of activity against most of clinical isolates tested its mean that Gatifloxacin is more effective than Levofloxacin. On the basis of present study it can be evaluated that levofloxacin and gatifloxacin were two very good antibacterial agent in the field of antimicrobial chemotherapy but different clinical isolates had started to develop resistance to those antibiotics, w/c is alarming because if organism started to develop resistance to these antibiotics than we will be left with no other choice of antibiotics