Evaluation of anti A60 IgM for the diagnosis of tuberculosis with ELISA method
Pakistan Journal of Pharmacology. 2011; 28 (2): 51-57
in English
| IMEMR
| ID: emr-178299
ABSTRACT
Evaluation of Anti Tuberculous IgM antibodies for rapid diagnosis of both pulmonary and extra-pulmonary tuberculosis. ELISA assay based on mycobacterial antigen A-60 [Anda Biologicals, France] was used on the sera obtained from 69 cases of Tuberculosis and 136 controls in the population of Karachi, Pakistan. Of 136 controls only 21.3% were positive for IgM antibodies and showing 78.7% specificity. A very high sensitivity 72.2% was seen in sputum positive active pulmonary tuberculosis. Relatively low 56.2% sero positivity was seen in cases of sputum negative active pulmonary tuberculosis compared to those of sputum positive pulmonary tuberculosis. In cases of extra pulmonary tuberculosis 57.8% sensitivity was observed. In cases of healed tuberculosis only 18.7% were found positive for IgM. The estimation value of IgM against A-60 for tuberculosis and the controls the global sensitivity of 62.2% and specificity of 78.7% was found when IgM estimation was taken into account
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Immunoglobulin M
/
Enzyme-Linked Immunosorbent Assay
/
Serologic Tests
/
Antigens, Bacterial
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Pak. J. Pharmacol.
Year:
2011
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