Biphasic response to luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress
IJMS-Iranian Journal of Medical Sciences. 2016; 41 (2): 118-125
in English
| IMEMR
| ID: emr-178553
ABSTRACT
Background:
Clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. Flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. However, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. This study was performed to investigate whether a cytoprotective concentration range of luteolin could be separated from a cytotoxic concentration range in human MG-63 osteoblast-like cells in high-glucose condition
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Iran. J. Med. Sci.
Year:
2016
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