Protection of hippocampal CA1 neurons against ischemia/reper-fusion injury by exercise preconditioning via modulation of Bax/ Bcl-2 ratio and prevention of caspase-3 activation

Nahid, Aboutaleb; Nabi, Shamsaei; Hamid, Rajabi; Mehdi, Khaksari; Sohaila, Erfani; Farnaz, Nikbakht; Pezhman, Motamedi; Ali, Shahbazi

Nahid, Aboutaleb; Nabi, Shamsaei; Hamid, Rajabi; Mehdi, Khaksari; Sohaila, Erfani; Farnaz, Nikbakht; Pezhman, Motamedi; Ali, Shahbazi.

Basic and Clinical Neuroscience. 2016; 7 (1): 21-30

in English | IMEMR | ID: emr-178780

ABSTRACT

ABSTRACT

Introduction:

Ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. The purpose of this study was investigating the effects of exercise preconditioning on expression of Bax, Bcl-2, and caspase-3 proteins in hippocampal CA1 neurons after induction of cerebral ischemia

Subject(s)

Animals, Laboratory; CA1 Region, Hippocampal; Hippocampus; Brain Ischemia; Exercise; bcl-2-Associated X Protein; Caspase 3; Rats, Wistar

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Index: IMEMR (Eastern Mediterranean) Main subject: Exercise / Brain Ischemia / Rats, Wistar / Bcl-2-Associated X Protein / Caspase 3 / CA1 Region, Hippocampal / Hippocampus Limits: Animals Language: English Journal: Basic Clin. Neurosci. Year: 2016

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