Journal of Reproduction and Infertility. 2016; 17 (2): 82-87
in English
| IMEMR
| ID: emr-178810
ABSTRACT
Background:
Growth factors play an essential role in the development of tumor and normal cells like testicular leydig cells. Treatment of cancer with anti-cancer agents like imatinib mesylate may interfere with normal leydig cell activity, growth and fertility through failure in growth factors' production or their signaling pathways. The purpose of the study was to determine cellular viability and the levels of, platelet derived growth factor [PDGF] and stem cell factor [SCF] in normal mouse leydig cells exposed to imatinib, and addressing the effect of imatinib on fertility potential
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Platelet-Derived Growth Factor
/
Stem Cell Factor
/
Leydig Cells
/
Mice
Limits:
Animals
Language:
English
Journal:
J. Reprod. Infertil.
Year:
2016
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