Protective Effect of selenium-based medicines on toxicity of three common organophosphorus compounds in human erythrocytes in vitro

ABSTRACT

Objective: Organophosphorus [OP] compounds are used to control pests, however they can reach the food chain and enter the human body causing serious health problems by means of acetylcholinesterase [AChE] inhibition and oxidative stress [OS]. Among the OPs, chlorpyrifos [CHP], malathion [MAL], and diazinon [DIA] are commonly used for commercial extermination purposes, in addition to veterinary practices, domestic, agriculture and public health applications. Two new recently registered medicines that contain selenium and other antioxidants, IMOD and angipars [ANG], have shown beneficial effects for OS related disorders. This study examines the effect of selenium-based medicines on toxicity of three common OP compounds in erythrocytes