Association of two polymorphic codons in P53 and ABCC1 promoter with prostate cancer
IJB-Iranian Journal of Biotechnology. 2015; 13 (1): 49-54
in English
| IMEMR
| ID: emr-179801
ABSTRACT
Background:
in prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 [MRP1] by an effect on promoter region
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Index:
IMEMR (Eastern Mediterranean)
Language:
English
Journal:
Iran. J. Biotechnol.
Year:
2015
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