Comparative analysis of first-degree relative's karyotype of mentally-retarded children with chromosome abnormalities and normal children

ABSTRACT

Background and Purpose: The first chromosomal abnormality was first reported in 1959 by Lujeune and his collogues and since then, studies have suggested the relationship between chromosomal abnormalities and retarded phenotype of the affected children. Nowadays, therefore, detecting chromosomal abnormalities is considered the primary diagnostic tool in congenital abnormalities including mental retardations. This study is, therefore, intended to compare the first-degree relatives' karyotoype of mentally-retarded children with such abnormalities with those of normal children