Non-functioning pituitary adenoma: clinicopathological study of 85 cases

ABSTRACT

Background and Purpose: Pituitary adenomas without clinically active hypertension are termed as non-functioning adenoma [NFPA]. These tumors represent about one quarter of all pituitary tumors. Immunohistochemical methods are the gold standard methods of identifying them. The Ki-67 is a nuclear antigen detected by the monoclonal antibody MIB-1, whose labeling index [LI] is considered as a marker of normal and abnormal cell proliferation