Role of immune system, apoptosis and angiogenesis in pathogenesis of rheumatoid arthritis and joint destruction A systematic literature review

ABSTRACT

Background:Rheumatoid arthritis [RA] is a chronic inflammatory disorder of unknown cause that is notorious for the chronic polyarticular synovial inflammation and progressive destruction of affected joints. Understanding the pathogenesis of RA provides the basis for optimal management of that disease in patients. The pathogenesis of RA largely explored in many studies in human as much as in mice models with collagen II induced arthritis, nevertheless the pathogenesis puzzle is still incomplete