Detection of TET2, KRAS and CBL variants by Next Generation Sequencing and analysis of their correlation with JAK2 and FLT3 in childhood AML
Egyptian Journal of Medical Human Genetics [The]. 2016; 17 (2): 209-215
in English
| IMEMR
| ID: emr-180240
ABSTRACT
Background:
Acute myeloid leukemia [AML] is a heterogeneous clonal disorder in terms of cytogenetic and molecular aberrations. Ten-Eleven-Translocation 2 [TET2], Kirsten rat sarcoma viral oncogene homolog [KRAS], and Casitas B-cell lymphoma [CBL] have an important role pathogenesis of acute myeloid leukemia [AML] and their activated mutations confer proliferative and survival signals
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Proto-Oncogene Proteins p21(ras)
/
Proto-Oncogene Proteins
/
Sequence Analysis, DNA
/
DNA-Binding Proteins
/
Proto-Oncogene Proteins c-cbl
/
Fms-Like Tyrosine Kinase 3
/
Janus Kinase 2
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Med. Hum. Genet.
Year:
2016
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