Partial association of restriction polymorphism of the ligand binding domain of human androgen receptor in prostate cancer
Egyptian Journal of Medical Human Genetics [The]. 2016; 17 (2): 223-228
in English
| IMEMR
| ID: emr-180242
ABSTRACT
Background:
Human androgen receptor [AR] functions as a steroid-hormone activated transcription factor. The receptor binds to its ligand [testosterone or dihydrotestosterone] and is translocated to the nucleus to stimulate the transcription of androgen responsive genes. Mutations in the ligand binding domain [LBD] impair the receptor activity and play a crucial role in the development and progression of prostate cancer [PCa]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Prostatic Hyperplasia
/
Binding Sites
/
Polymorphism, Restriction Fragment Length
/
Receptors, Androgen
/
Ligands
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Egypt. J. Med. Hum. Genet.
Year:
2016
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