MMP9 promoter polymorphism [-1562 C/T] does not affect the serum levels of soluble MICB and MICA in breast cancer

ABSTRACT

Background: the role of Matrix Metalloproteinase 9 [MMP9] in tumor invasion and progression is prominent. A single nucleotide polymorphism [SNP] in the promoter region of MMP9 [-1562 C/T] increases the transcription and expression of this gene. On the other hand, MHC class I chain-related protein A and B [MICA/B] in soluble forms may impair tumor immunogenicity by reducing Natural Killer Group 2D [NKG2D] densities on NK cells and MMP9 enzyme activity has a prominent role in shedding of MICA/B