Expression profile of RabS, Rab7, tryptophan aspartate-containing coat protein, leprae lipoarabinomannan, and phenolic glycolipid-1 on the failure of the phagolysosome process in macrophages of leprosy patients as a viability marker of Mycobacterium leprae

ABSTRACT

Objective/Background: phagolysosome process in macrophage of leprosy patients' is important in the early phase of eliminating Mycobacterium leprne invasion. This study was to clarify the involvement of Rab5, Rab7, and trytophan aspartate-containing coat protein [TACO] from host macrophage and leprae lipoarabinomannan [Lep-LAM] and phenolic glycolipid-1 [PGL-1] from M. leprne cell wall as the reflection of phagolysosome process in relation to 16 subunit ribosomal RNA [16S rRNA] M. leprne as a marker of viability of M. leprae