[Risk Factors of side effects of antituberculosis drugs]

ABSTRACT

The aim of this study was to determine the side effects of standard antituberculosis therapy with isoniazid, rifampicin. pyrazinamide and streptomycine in patients treated for tuber-culosis. One hundred eighty nine patients with proven tuber-culosis, who initially received standard antituberculosis the-rapy, were retrospectively studied. Begaud and coil's method of side effects drugs imputability elaborated in 1999 was used in our study.Side effects related to therapy were present in 31.7% of the studied population.Gastrointestinal side effect was the most common [13.2%], isoniazid, rifampicin and pyrazinamide were often incriminated. The significant risk factors of hepatotoxicity were female gender [OR 10.59] and concomitant hepatotoxic drugs [OR 6]. Chocleovestibular toxicity was associated significantly with female gender [OR 8.03] and diabetes mellitus [OR 6.13]. Patients aged above 50, proved to be at risk for pyrazinomide intolerance and females for streptomycine. The study did not reveal any susceptibility to isoniazid and rifadine intolerance