Study of thrombomdulin, cytokines and adhesion molecules as a marker of disease activity in systemic lupus erythematosus

ABSTRACT

Twenty-four female patients with SLE compared with ten normal females as control subjects were included in this study. They were classified into 3 groups Group I 10 patients with SLAM score < 9 [low activity], Group II 14 patients with SLAM score > 9 [high activity], Group III 10 normal control subjects. All groups were subjected for specific laboratory investigations including Thrombornodulin [TM mg/dl] Adhesion molecules soluble intercellular adhesion molecule -1 [ICAM- 1], soluble vascular cell adhesion molecule [VCAM -1] and soluble E- selectin [ng/ ml] Cytokines Interleukin 6 [IL-6] and Interleukin - 10 [IL- 10][pg/ml]. The result showed Significant increase of TM, IL-6, IL-10, ICAM, VCAM, and E-selectin in group II compared with group III [p<0.01 and <0.05].Significant increase of VCAM level in group I compared with group III [p<0.001], but insignificant difference of TM, IL-6, IL- 10, ICAM and E-selectin between both groups.There were significant increase of TM, IL-6 and IL- 10 in group II [highly active] when compared with group I [low active] patients [p<0.01, <0.01 and <0.01] respectively, but insignificant difference of VCAM, ICAM, and E- selectin between both groups. There was significant correlation between TM, IL-6, IL-10,VCAM, E Selectin levels and disease activity in SLE patients [r= 0.701, 0.769, 0.696, 0.624, 0.904]respectively,and [pdisease activity in SLE patients but cytokines [IL-6 and IL- 10] and adhesion molecules [ICAM, VCAM, and E-selectin] are recent serological parameters for disease activity of SLE patients