N-acetyltransferase activity in bilharzial infested mice

ABSTRACT

N-acetyltransferase enzyme systems act as components of detoxication pathway with respect at arylamine induced bladder carcinogenesis. The percent of N-acetylation of sulphadiazine was estimated in serum, liver and doudenum of bilharzial infested mice, as well as in normal control animals. Liver homogenates showed the highest% of N-acetylation, whether in normal or bilharzial infested mice. Nevertheless, the percent of N-acetylation was significantly decreased in bilharzial infested mice as compard to normal untreated controls. This decrease was obvious in serum, liver and doudenal tissue homogenates. These findings indicates that bilharzial infested subjects might be at a high risk of having bladder cancer after exposure to arylamine. In this respect, N-acetylation could be used as a determinant of the susceptibility of individuals to arylamine bladder carcinogenesis