Metabolomic analysis of human cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis diseases
Gastroenterology and Hepatology from Bed to Bench. 2016; 9 (3): 158-173
in English
| IMEMR
| ID: emr-181030
ABSTRACT
Metabolome analysis is used to evaluate the characteristics and interactions of low molecular weight metabolites under a specific set of conditions. In cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease [NAFLD] and non-alcoholic steatotic hepatitis [NASH] the liver does not function thoroughly due to long-term damage. Unfortunately the early detection of cirrhosis, HCC, NAFLD and NASH is a clinical problem and determining a sensitive, specific and predictive novel method based on biomarker discovery is an important task. On the other hand, metabolomics has been reported as a new and powerful technology in biomarker discovery and dynamic field that cause global comprehension of system biology. In this review, it has been collected a heterogeneous set of metabolomics published studies to discovery of biomarkers in researches to introduce diagnostic biomarkers for early detection and the choice of patient-specific therapies
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Index:
IMEMR (Eastern Mediterranean)
Type of study:
Screening study
Language:
English
Journal:
Gastroenterol. Hepatol. Bed Bench
Year:
2016
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