[Design the new virus HTLV-1 protease peptide inhibitors based on Benzene functional group by computational methods]

ABSTRACT

Background: Virus htlv-1 is in the retrovirus family; the virus causing human diseases such as adult T-Cell Leukemia [ATL], HAM / TSP and etc… One of the major proteins in the virus is protease that is essential for virus maturation. Inhibitors that ever made for the protease didn't show any properly activity. We have created a new series of inhibitors and with using of computational tools to calculate the way of interactions to the protease protein.