[ Effect of Metformin on spatial learning and memory in streptozotocin Rat Model of Alzheimer's Disease]

ABSTRACT

Background:Alzheimer's disease [AD] is closely associated with impaired insulin signaling in brain, suggesting it to be a brain-specific form of diabetes and so termed as "type 3 diabetes". Therefore investigating the role of pharmacological agents that can improve neuronal insulin resistance merit attention in treatment off AD. Metformin is one of the most widely used against peripheral insulin resistance. In present study, we aimed to investigate the therapeutic efficacy of metformin on spatial learning and memory of streptozotocin [STZ] Rat Model of AD.