[Association between Interleukin-18 -607A/C gene polymorphism and the concentration of serum IgE as a risk factor for allergic rhinitis]

ABSTRACT

Background: Allergic rhinitis is a chronic inflammatory disease of the upper airways, this inflammatory response in the nasal mucosa includes an immediate IgE-mediated response. IL-18, a member of the IL-1 family, is known for influencing the balance of IgE level. In present study this problem is investigated that whether immunoglobulin [Ig] E levels in serum are associated with -607A/C SNPs of IL18 promoter.