[Effect of Rasburicase in renal function in children with acute kidney injury in Sheikh Children's Hospital]

ABSTRACT

Aims: Acute kidney injury [AKI] is characterized by a reversible increase in the blood concentration of creatinine and nitrogenous waste products and by the inability of the kidney to regulate fluid and electrolyte homeostasis appropriately. Hyperuricemia is a feature of several pathologies and requires an appropriate and often early treatment, owing to the severe consequences that it may cause. A rapid and massive raise of uric acid, mainly damage the kidney.. Rasburicase, compared to allopurinol, results in more rapid reduction of uric acid and prevent its accumulation in patients with hematologic malignancy with hyperuricemia and AKI.