effect of plasma exchange on theexpression of FOXP3 and rorc2 inrelapsed multiple sclerosis patients

ABSTRACT

Background: Lack of sufficient information on the mechanism of plasma exchange[PE] therapy in multiple sclerosis [MS], has limited this treatment to individual patientswith severe relapses who have been refractory to other treatments. This is while PE isused very successfully as a first-line standard treatment in many other neuro-immunedisorders. Recent data suggest that Treg/Th17 counterbalance may indicate theboundaries between promotion and regulation of inflammatory responses in MS andTreg/Th17 ratio may be useful as a marker for monitoring the efficiency of MStherapies