Antiviral potential of a diterpenoid compound sugiol from Metasequoia glyptostroboides

ABSTRACT

This research reports first time antiviral activity of sugiol, a diterpenoid isolated from Metasequoia glyptostroboides in terms of its ability to inhibit in vitro growth of HiNi influenza virus. Antiviral potential of sugiol was evaluated through cytopathogenic reduction assay using Madin-Darby canine kidney [MDCK] cell line. Sugiol [500 jug/ml] was found to exhibit considerable anti-cytopathic effect on MDCK cell line confirming its antiviral efficacy against HiNi influenza virus. These findings strongly reinforce the uf gestion that sugiol could be a candidate of choice in combinational regimen with potential antiviral efficacy