Detection of influenza B viruses with reduced sensitivity to neuraminidase inhibitor in Morocco during 2014/15 season
EMHJ-Eastern Mediterranean Health Journal. 2016; 22 (7): 452-458
in English
| IMEMR
| ID: emr-181501
ABSTRACT
We monitored phenotypic and genotypic susceptibility of influenza viruses circulating in Morocco during 2014-2015 to oseltamivir and zanamivir. Throat and nasal swab specimens were collected from outpatients [with influenza-like illness] and inpatients [with severe acute respiratory illness] and tested for influenza viruses using real-time reverse transcription polymerase chain reaction. Positive samples were inoculated in MDCK cells and virus phenotypic susceptibility to neuraminidase inhibitors [NAIs] was assessed using fluorescent NA inhibition. Of 440 specimens, 135 were positive for influenza B Yamagata-like virus, 38 were A[H1N1] pdm09 and 25 were A[H3N2]. Sixty influenza B viruses isolated from MDCK cells showed no significant resistance to NAIs. However, two of these strains, B/Morocco/176H/2015 and B/Morocco/CP10/2015, showed reduced susceptibility to oseltamivir. The two influenza B viruses with reduced susceptibility to oseltamivir show that ongoing NAI susceptibility surveillance is essential
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Respiratory Tract Infections
/
Oseltamivir
/
Zanamivir
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Infant, Newborn
Language:
English
Journal:
East Mediterr Health J.
Year:
2016
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