Synthesis of biologically active 3 bromo-1: 8-naphthalylamino acid dipeptide derivatives

Synthesis of a series of 3-bromo-l: 8-naphthalylamino acids [II-VIII] and their corresponding methyl esters [IX-XIII]is described. Coupling of 3-bromo-l: 8-naphthalylamino acids with amino acid methyl ester hydrochlorides [or urea or 2-amino-pyridine] in dioxane-DMF-Et, N medium using DCC method, furnishes the desired 3-bromo-l: 8-naphthalyldipeptides[XIV-XXVIII]. All 3-bromo-l-8-naphthalyl derivatives of L-valine, L-leucine, DL-phenylalamtie and [S-alanine and their methyl esters and most dipeptide derivatives were found to possess high antimicrobial activities towards different microorganisms