Protective effects of rice bran oil in haloperidol-induced tardive dyskinesia and serotonergic responses in rats

ABSTRACT

Effect of administration of Rice bran oil [RBO] was evaluated on haloperidol elicited tardive dyskinesia in rats. Albino Wistar rats treated with haloperidol in drinking water at a dose of 0.2mg/kg/day and RBO by oral tubes at a dose of 0.4 mL/day for 5 weeks. Motor coordination, VCMs and 8-hydroxy-2-[di-n-propylamino] tetraline][8-OHDPAT] _syndrome were monitored. Striatal serotonin [5-hydroxytryptamine; 5-HT] and 5-hydroxyindolacetic acid [5- HIAA] levels were determined by high performance liquid chromatography [HPLC-EC]. Rats treated with haloperidol orally at a dose of for a period of 5 weeks developed VCMs, which increased progressively as the treatment continued for 5 weeks. Motor coordination impairment started after the 1[st] week and was maximally impaired after 3 weeks and gradually returned to the 1[st] week value. Co-administration of RBO prevented haloperidol_induced VCMs as well impairment of motor coordination. The intensity of 8-OH-DPAT_induced syndrome and decreased 5-HT metabolism were greater in water + haloperidol treated animals than RBO + haloperidol treated animals. The present study suggested that involvement of free radical in the development of TD and point to RBO as a possible therapeutic option to treat this hyperkinetic motor disorder