Evaluating the effect of infliximab on the healing of left colonic anastomosis in the presence of intra-abdominal sepsis

ABSTRACT

Background and study aims: infliximab [IFX] is a chimeric anti-TNF-alpha body which is effectively used in the treatment of inflammatory bowel diseases and a variety of autoimmune diseases. The effect of IFX on the healing of intestinal anastomosis has been evaluated studies, however with conflicting results. Furthermore, the effect of IFX on colonic anastomosjs in sepsis has not been evaluated to date. In this study, we aimed to investigate whether IFX has an adverse effect on the healing process of colonic anastomosis either under normal or septic condition