Experimental study of the possible effect of valsartan on insulin resistance in fructose- fed albino rats
Mansoura Medical Journal. 2006; 37 (1-2): 363-379
in English
| IMEMR
| ID: emr-182176
ABSTRACT
Insulin resistance [IR] is a consequence of high fructose fed diet in rats. The current study was carried out to declare if tumor necrosis factor alpha [TNF-alpha] exerts a partial role the development of IR in non-obese rat model; fructose fed rats [FFR] like that happens in obese rat models. We evaluate the influence of valsartan [a selective blocker of angiotensin receptor type-1] in comparison to metformin [a known insulin sensitizer] on enhancement of insulin sensitivity in FFR. Rats were divided into 2 equal groups [36 rats /group], one group received high fructose diet to induce insulin resistance and the other included standard diet fed rats. Each group is further divided into 3 equal subgroups, [standard diet+ saline], [FFR+ saline], [Standard diet + metformin], [FFR+ metformin]. [Standard diet+ valsartan] and [FFR+ valsartan]. In all rats, body weight, fasting serum glucose, fasting serum insulin, insulin sensitivity test, fasting glucose insulin ratio [FGIR], serum TNF-alpha and serum malondialdehyde [MDA] were measured. Result revealed that administration of valsartan to FFR produced a comparable improvement of insulin resistance. In addition valsartan treatment in FFR produced significant decrease in serum TNF-alpha and MDA. It could be concluded that TNF-alpha and angiotensin II might regulate insulin sensitivity in non-obese FFR
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Valine
/
Tumor Necrosis Factor-alpha
/
Mice, Inbred NOD
/
Receptor, Angiotensin, Type 1
/
Fructose
/
Malondialdehyde
/
Metformin
Limits:
Animals
Language:
English
Journal:
Mansoura Med. J.
Year:
2006
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