[Thyroid autoantibodies in chronic urticaria]

ABSTRACT

Osteoporosis is the most common metabolic bone disease with significant morbidity and mortality. This study is a part of national study of osteoporosis in Iran. We studied the prevalence of osteoporosis and osteopenia in Mashhad and correlation of bone mineral density with age, height, weight and BMI. Also, we studied correlation between bone mineral densities in different skeletal regions. We also determine prevalence of low bone mass in Mashhadian women based on Mashhadian women reference population. 1003 persons from Mashhad citizens [631 women and 372 men], aged between 20-79 years were selected by random cluster sampling from 2000 through 2003. Those who had known diseases or used medications affecting bone mineral density were excluded based on history and physical examination. We used LUNAR [DPX-IQ] device for densitometry and WHO criteria for interpretation. SPSS [11.5] used for analysis of data and P value less than 0.05 considered as significant. Mean of age, height, weight and BMI was 42.02 +/- 12.77 years, 157.66 +/- 7.16 centimeter, and 69.11 +/- 12.24 kilogram and 27.83 +/- 4.8 kg/m[2], respectively. Mean of age in men and women was similar but mean of height, weight and BMI was higher in men and difference between men and women in height, weight and BMI was significant. There was a positive, significant correlation between bone mineral density in vertebral column and femoral neck regions and correlation coefficient [r] between them was 0.7. There was a positive significant correlation between bone mineral density and following parameters height, weight and BMI. Correlation between BMD and age was negative and significant. In women prevalence of low bone mass with US/European reference population was higher than with Mashhadian reference population. These findings support the importance of regional reference population for better interpretation of BMD results. Finally, prevalence of osteopenia and osteoporosis in Mashhad was 46.8% and 12.6%, respectively. Osteoporosis is a health problem in Mashhad. So we encourage preventive measures such as modification of nutrition, adequate Calcium and Vitamin D intake and life style modification. We emphasize on using of regional reference population for interpretation of densitometry results. Because of correlation coefficient [r] of bone mineral density in different sites of skeleton is 0.7; we recommend that bone densitometry should be done both in vertebral column and femoral regions