[ effect of polycystic ovaries syndrome on outcome of assisted reproductive technology in Isfahan Infertility Center-2003]

ABSTRACT

Polycystic ovaries syndrome [PCOS] is a very common endocrine disorder in infertile women with unovulatory cycle. This disorder is associated with abnormal circulating hormones. The response of ovaries to induction of ovulation is a contraversial issue and can have different results. This study tried to comapre the results of induction for ovulation in 130 patients who had polycystic ovary syndrome with that of 130 women who had tubal factor for infertility and had normal ovaries. In this prospective study, there were 260 women having PCOS and tubal infertility, undergoing Invitro Fertilization [IVE] and Intracytoplasmic Sperm Injection [ICSI] treatment in Isfahan infertility center. The number of oocyte. concentration of testosterone and andrestandion, fertility rate and embryo quality were compared. The findings showed that the mean of oocyte retrieved [13.1 versus 8.04], concentration of andrestandion in follicular and LH0 and testosterone in LH0 phase were higher in PCOS patients. The fertilization rate in PCOS patients [64%] showed no difference with tubal factor [67%]. The findings showed that the induction for ovulation in PCOS is followed by increasing serum androgen concentration through its effect on early embryonic development but due to high number of oocyts and embryo in PCOS patients versus patients with normal ovaries, the chance of more embryos with ideal quality is increased by number of oocytes and subsequently embryos earned by IVF/ICSI technique