BIRC5 genomic copy number variation in early-onset breast cancer

ABSTRACT

Background: Baculoviral inhibitor of apoptosis repeat-containing 5 [BIRC5] gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. The copy number of BIRC5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood