[Effect of celecoxib on serum visfatin levels in streptozotocin-induced diabetes in male rats: role of nitrergic system]

ABSTRACT

Background and Aim: Nicotinamide phosphoribosyltransferase [NAMPT]/ [visfatin] have been proposed as proinflammatory cytokine that is influenced by blood glucose or insulin. In diabetes mellitus proinflammatory agents such as prostaglandin E2 and nitric oxide can increase visfatin synthesis and visfatin stimulates their expression. The aim of this study was to determine the effect of cyclooxygenase and nitrergic system on serum visfatin level and some biochemical parameters in diabetic rats