Histological evaluation of hydroxyapatite granules with and without platelet-rich plasma versus an autologous bone graft comparative study of biomaterials used for spinal fusion in a New Zealand white rabbit model

ABSTRACT

Objectives: Hydroxyapatite [HA] has osteoconductive properties and is widely used as a bone graft substitute. Platelet-rich plasma [PRP] is an autologous product with osteoinductive effects. Hypothetically, a combination of both would augment the bone formation effect of HA and widen its application in spinal fusion surgeries. This study aimed to compare new bone formation with HA granules alone and in combination with PRP versus an autologous bone graft during a lumbar intertransverse process spinal fusion