Amelioration of insulin resistance in rats treated with rice bran oil

ABSTRACT

Background: insulin resistance [IR] is a pathological condition characterized by inadequate peripheral tissue metabolic response to circulating insulin. It plays pathophysiological role in type 2 diabetes mellitus [T2DM]. High dosage of fructose in the diet [60 g/100 g diet] may induce insulin resistance accompanied by deleterious metabolic consequences including hyperglycemia and hyperinsulinemia. Rice bran oil [RBO], is a rich source of antioxidants especially gamma-oryzanol, alpha-tocopherols and tocotrienols which contribute to high oxidative stability, longer shelf life than other edible oils and high antioxidant property against free radicals. The present work was undertaken to study if the addition of rice bran oil in rat's diets ameliorate the insulin resistance