Drug delivery through denture-base resins - a systematic review

ABSTRACT

The purpose of this article was to review current literature on the usage of denture bases as potential drug-release devices DRDs] for the treatment of oral conditions such as Candida associated denture stomatitis [CAD] and recurrent ulcers. Relevant publications from the year 1983 to 2014 were included by searching 'denture bases' and 'drug delivery' using [MeSH terminology]. Specific inclusion and exclusion criteria were set. Most studies were done in vitro. It was concluded during the review that various therapeutic agents such as Fluconazole, Chlorhexidine gluconate and Hydrocortisone Sodium Succinate have been successfully incorporated in denture base resins. Drugs leach out steadily from poly methyl methacrylate [PMMA] specimens for a period of 28 days. In case of rechargeable denture bases, the elution continues for longer periods. A lot of ongoing research is being done on the incorporation of silver nanoparticles and monitoring its antimicrobial activity