Double-hit lymphoma -a rare subset of diffuse large b cell lymphoma with poor outcome

ABSTRACT

Double-hit lymphoma [DHL] has been identified as a subset of diffuse large B-cell lymphoma with poor clinical outcomes. It is because of genetic translocation of C-myc and Bc12 gene that make it more aggressive and un-responsive to conventional and salvage treatments. DHL is an extremely rare entity of non-Hodgkin's lymphoma [NHL] having no established incidence data so far. In literature very limited data is available to guide therapeutic decisions and despite aggressive chemotherapy followed by autologus hematopoietic cell transplantation, outcomes still remain poor. Herein, we report a case of 82-year Pakistani patient who presented with left groin lump. Incision biopsy established the diagnosis of DHL. Despite intensive course of standard chemotherapy and radiation therapy, he died with progression of disease