cytotoxicity of dacarbazine potentiated by sea cucumber saponin in resistant B16F10 melanoma cells through apoptosis induction

ABSTRACT

Background: Malignant melanoma is a highly aggressive malignant melanocytic neoplasmwhich resists against the most conventional therapies. Sea cucumber as one ofmarine organisms contains bioactive compounds such as polysaccharide, terpenoidand other metabolites which have anti-cancer, anti-tumor, anti-inflammatory andantioxidant properties. The present study was designed to investigate the anticancerpotential of saponin extracted from sea cucumber Holothuria leucospilata alone andin combination with dacarbazine on B16F10 melanoma cell line