Double-blind comparison of loperamide and placebo against acute diarrhoea in adults

ABSTRACT

In a randomized double-blind study involving 93 adult patients, loperamide significantly reduced the number of loose stools and the time until the first solid stool, but there was no significant effect on fluid requirements. Side-effects were limited to two patients one receiving placebo developed a rash, and one patient taking loperamide reported constipation on the second day of treatment